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22 Mar 2021
  • Victorian Comprehensive Cancer Centre
  • St Vincent's Institute

Monday Lunch Livestream with Professor Louise Purton

Key roles of Hoxa1 in HSCs and myelodysplastic syndromes

Myelodysplastic syndromes (MDS) is a malignant blood cell disease that predominantly results in bone marrow failure, where patients die from complications relating to low blood cell counts. It is a heterogeneous disease and approximately thirty percent of patients progress to acute myeloid leukaemia. Aside from stem cell transplants, which most patients are ineligible for due to their older age, there is no cure.

Hear from Professor Louise Purton (Head, Stem Cell Regulation Unit, St Vincent’s Institute of Medical Research), who will review the role of the altered HOXA1 gene in MDS and how it affects the ability of HSCs to form blood cells. Her presentation will explore how mouse models of MDS with altered HOXA1 expression can be used to understand what changes occur in the HSCs to cause MDS, identify targets and improve therapeutic options for patients suffering from this disease.

Louise Purton head shot 2018

Professor Louise Purton

Professor Louise Purton established and is Head of the Stem Cell Regulation Unit at St Vincent’s Institute of Medical Research. Her research involves how haematopoiesis is regulated both intrinsically and extrinsically in normal and diseased states. Louise has a passion for translational research and to date, her research has resulted in four clinical trials. She is internationally recognised and has received funding from numerous national and international funding bodies including; NHMRC, NIH, Leukaemia and Lymphoma Society of America (LLSA), Worldwide Cancer Research. Additionally, she has held Fellowships from NHMRC and LLSA.

Monday 22 March