Adolescents to Adult Trials
How can we get adolescents to adult oncology trials?
For adolescents (15-17 years), access to an adult hospital is not a barrier to adult cancer trial participation, since most adult hospitals routinely admit patients from 15 or 16 years of age. Rather, the primary barrier is that adult cancer trials very rarely have an age eligibility below 18 years.
To begin to alleviate this, the VCCC approached the Therapeutic Goods Administration (TGA) and asked them to consider adopting the US Food and Drug Administration (FDA) guideline: Considerations for inclusion of adolescent patients in adult oncology clinical trials – Guidance for Industry.
The adoption by the TGA of the FDA guideline supports and facilitates, for the first time in Australia, a lowering of the age eligibility in relevant adult cancer clinical trials to include adolescents.
It is anticipated that, over time, use of the guidance will lead to an increase in availability of clinical trials for the approximately 300 adolescents and young adults (AYA) patients, who are diagnosed with cancer in Victoria every year.