Ethics, Governance and Collaborations
Establishing clinical trials involving both adult and paediatric participants can be difficult to navigate.
How do I get ethics and governance approval to open an AYA clinical trial?
The Adolescent and Young Adult (AYA) Research Ethics and Governance Guideline provides a path to successful approval of clinical trial protocols that have an age eligibility, encompassing both adult and paediatric participants.
The guideline includes information on:
- Importance of justification of age eligibility based on disease biology
- Consent processes for paediatric participants
- Selecting an appropriate Human Research Ethics Committee
- Protocol amendments to broaden age eligibility in currently open trials
How can we get paediatric and adult oncology teams to communicate more about clinical trials?
The Paediatric-Adult Oncology Framework assists in the establishment of deliberate relationship-building between paediatric and adult oncology.
Focussed on systems-level issues, these ‘AYA craft groups’ aim to:
- Ensure clinician awareness of clinical trials on both sides of the paediatric-adult care divide
- Avoid duplication of trials between paediatric and adult oncology
In addition, AYA craft groups present opportunities to build collaborative research relationships; potentially leading to an increased number of investigator-initiated trials, designed to accommodate AYA participation.